In the study, the weight loss drug Altimmune minimized the loss of muscle mass

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on Wednesday he said yes experimental drug helped patients lose weight, but in addition minimized loss of muscle mass midway through the study, which could set it apart in a potentially crowded market.

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Altimmune is one of several smaller biotech firms which are attempting to compete directly with the growing weight loss drug space and market, or wish to be acquired by larger drugmakers that may also help bring their therapies to market.

The results are an early sign that the biotech company can solve a serious problem with these treatments, which have generated sustained demand and investor interest over the past yr.

Some health experts say obesity medications can reduce critical muscle mass, which may increase the risk of injury and reduce strength.

However, in keeping with Altimmune, in the late-stage Altimmune study, greater than 74% of the body weight patients lost after receiving the weekly injections got here from fat tissue and only 25.5% from fat-free mass. These results are much like those often seen with weight loss plan and exercise programs.

According to the company, patients who took a 2.4-milligram dose of Altimmune weekly for 48 weeks lost a mean of 15.6% of their body weight in the study, and the weight loss was maintained after treatment ended.

First the company announced data on a weight loss drug called pemvidutide in November.

“Preserving fat-free mass during weight loss is crucial because excessive loss of fat-free mass is associated with negative effects such as [a gradual loss of muscle mass and strength] and bone fractures, especially in women and older people,” Altimmune Chief Medical Officer Scott Harris said in an announcement. “There is a growing awareness that the quality of weight loss is as important as the quantity of weight loss.”

In a clinical trial of semaglutide, the lively ingredient in Novo Nordisk’s Ozempic and Wegovy, researchers examined the loss of lean muscle mass in a subgroup of roughly 140 patients. During the 68-week study, participants lost a mean of about 15 kilos of lean muscle mass and 23 kilos of fat.

These results suggest a better rate of fat-free mass decline than in the Altimmune study. Still, Altimmune must conduct late-stage studies on its drug, so it’s too early to find out what advantage it has over existing weight loss treatments.

The two drugs also work in a different way.

Semaglutide mimics a hormone produced in the gut called GLP-1 to suppress appetite. Meanwhile, Altimmune prompts GLP-1 and one other gut hormone called glucagon, which increases energy expenditure.

Altimmune can be developing this drug to treat a typical form of liver disease called metabolic dysfunction-associated steatohepatitis (MASH).

Other obesity drug makers are also attempting to help patients maintain muscle mass.

For example, Eli Lilly is testing whether combining a weight-loss drug with Versanis Bio’s monoclonal antibody may also help patients lose weight while maintaining muscle mass. The pharmaceutical giant recently acquired Versanis, which is a component of a bunch of firms coping with the aspect of muscle loss.

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Rome: Visionary Founder of the GlobalCommand Ecosystem (GlobalCmd.com | GLCND.com | GlobalCmd A.I.) Rome is the innovative mind behind the GlobalCommand Ecosystem, a dynamic suite of platforms designed to revolutionize productivity for entrepreneurs, freelancers, small business owners, and forward-thinking individuals. Through his visionary leadership, Rome has developed tools and content that eliminate complexity, empower decision-making, and accelerate success. The Powerhouse of Productivity: GlobalCmd.com At the heart of Rome’s vision is GlobalCmd.com, an intuitive AI-powered platform designed to simplify decision-making and streamline workflows. Whether you’re solving complex business challenges, scaling a new idea, or optimizing daily operations, GlobalCmd.com transforms inputs into actionable, results-driven solutions. Rome’s approach is straightforward yet transformative: provide users with tools that deliver clarity, save time, and empower them to focus on growth and achievement. With GlobalCmd.com, users no longer have to navigate overwhelming tools or inefficient processes—Rome has redefined productivity for real-world needs. An Ecosystem Built for Excellence Rome’s vision extends far beyond productivity tools. The GlobalCommand Ecosystem includes platforms that address every step of the user’s journey: • GLCND.com: A professional blog and content hub offering expert insights and actionable advice across business, science, health, and more. GLCND.com inspires users to explore new ideas, sharpen their skills, and stay ahead in their fields. • GlobalCmd A.I.: The innovative AI engine powering GlobalCmd.com, designed to turn user inputs into tailored recommendations, predictive insights, and actionable strategies. Built on the cutting-edge RAD² Framework, this AI simplifies even the most complex decisions with precision and ease. The Why Behind GlobalCmd.com Rome understands the pressure and challenges of running a business, launching projects, and making impactful decisions in real time. His mission was to create a platform that eliminates unnecessary complexity and provides clear, practical solutions for users. Whether users are tackling new ventures, refining operations, or handling day-to-day decisions, Rome has designed the GlobalCommand Ecosystem to meet real-world needs with innovative, results-oriented tools. Empowering Success Through Simplicity Rome’s ultimate goal is to empower individuals with the right tools, insights, and strategies to take control of their work and achieve success. By combining the strengths of GlobalCmd.com, GLCND.com, and GlobalCmd A.I., Rome has created an ecosystem that transforms how people work, think, and grow. Start your journey to smarter decisions and greater success today. Visit GlobalCmd.com and take control of your future.

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